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  • Title: IgE mediated hypersensitivity in children with idiopathic nephrotic syndrome.
    Author: Rebien W, Müller-Wiefel DE, Wahn U, Schärer K.
    Journal: Int J Pediatr Nephrol; 1981 Mar; 2(1):23-8. PubMed ID: 7333765.
    Abstract:
    Sixty children with idiopathic nephrotic syndrome (NS) and 30 unselected controls were studied for IgE mediated hypersensitivity by skin-test, total serum IgE and specific IgE antibodies to various allergens. In 42 patients the NS was steroid-responsive and associated with minimal glomerular changes (MC); in 18 patients it was steroid-resistant and associated with focal-segmental glomerulosclerosis (FSS). A history of allergy was found in 17% of MC, 6% of FSS and 10% of control children. Neither serum IgE concentration nor the incidence of allergen specific IgE antibodies were significantly different between the 3 groups. In the presence of steroid-dependency the prevalence of atopy appeared to be higher. However, our data do not support the hypothesis that for the pathogenesis of NS IgE mediated hypersensitivity plays a general role.
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