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  • Title: Anticancer indole alkaloids of Rhazya stricta.
    Author: Mukhopadhyay S, Handy GA, Funayama S, Cordell GA.
    Journal: J Nat Prod; 1981; 44(6):696-700. PubMed ID: 7334384.
    Abstract:
    The leaves and roots of Rhazya stricta (Apocynaceae) yielded four indole alkaloids. Three of these isolated, vallesiachotamine (1), sewarine (3) and tetrahydrosecamine (4), displayed cytotoxic activity; polyneuridine (2) was not reported previously from this species. Tetrahydrosecaminediol (5), its acetate 6, and didemethoxycarbonyl-tetrahydrosecamine (7) were prepared from tetrahydrosecamine (4) by chemical reactions. The diol 5 was highly cytotoxic.
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