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  • Title: [Renovascular hypertension: prediction of surgical treatment by angiotensin II blockade and saralasin (author's transl)].
    Author: Mimran A, Deschodt G, Barjon P, Mary H, Thevenet A.
    Journal: Nouv Presse Med; 1978 Dec 02; 7(43):3889-93. PubMed ID: 733540.
    Abstract:
    The response of arterial pressure to an infusion of saralasin was compared to the effect of surgical correction of renal vascular lesions (3 to 6 months after surgery) in eleven patients whose hypertension was associated with uni or bilateral stenosis of renal artery. Saralasin was infused after four days of dietary sodium restriction (10--40 mEq/day). An excellent correlation (r = 0.83, p less than 0.005) between the effects of saralasin and surgery was obtained. There was no correlation between the response to saralasin or to surgery and the ratio of renal vein renin activities. It is suggested that saralasin may be a good tool for predicting the effect of surgery in renovascular hypertension, when infused in moderately sodium depleted patients.
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