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  • Title: [Effect of remantadine on the development of toxicoses caused by different strains of influenza virus].
    Author: Kiseleva IV.
    Journal: Vopr Virusol; 1981; (5):541-3. PubMed ID: 7336681.
    Abstract:
    The effect of remantadine on the development of viral toxicosis caused in mice by original and remantadine-resistant strains of influenza virus was studied. A definite reduction of the antitoxic effectiveness of remantadine was demonstrated in passages of toxigenic influenza A virus strain in its presence. Prophylactic administration of remantadine protected mice from the development of toxic pulmonary edema and death caused by inoculation of a massive dose of influenza B virus. Passages of influenza B virus in the presence of remantadine produced a strain causing toxicosis in mice the course of which was not affected by remantadine any longer.
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