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  • Title: Alpha-methylhistamine methylation by histamine methyltransferase.
    Author: Hough LB, Khandelwal JK, Mittag TW.
    Journal: Agents Actions; 1981 Nov; 11(5):425-8. PubMed ID: 7337069.
    Abstract:
    Enzymatic methylation of histamine and analogues by histamine methyltransferase (HMT) was studied. Incubation of histamine or alpha-methylhistamine with HMT and S-adenosylmethionine was shown by GC-MS to yield tele-methyl and alpha-methyl-tele-methyl-histamine, respectively. Kinetic analysis of the reactions indicated that both substrates exhibited equivalent Vmax values, but that histamine's Km was ten-fold lower than that of alpha-methylhistamine. These results indicate that alpha-methylhistamine can be methylated as effectively as histamine, and may be a useful tool in further studies of HMT.
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