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  • Title: Further studies on the mechanism of action of methyldopa on the vas deferens of the guinea-pig.
    Author: Tayo FM.
    Journal: Arch Int Pharmacodyn Ther; 1981 Nov; 254(1):38-42. PubMed ID: 7337493.
    Abstract:
    Methyldopa (400 micrograms/ml) abolished neurally evoked contractions of the guinea-pig vas deferens after 1.5 hr incubation. The tissue became supersensitive to noradrenaline and acetylcholine but was now insensitive to potassium chloride. On the other hand, tissues treated with 6-hydroxydopamine (6-OHDA) were supersensitive to noradrenaline but not to acetylcholine. The results suggest that cholinergic mechanisms may also be affected by methyldopa.
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