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  • Title: [The hemodynamic effects of reproterol in patients with chronic obstructive lung disease (author's transl)].
    Author: Bonaduce D, Ferrara N, Canonico V, Cocozza M, Petretta M, Romano E, Rengo F.
    Journal: G Ital Cardiol; 1981; 11(10):1467-71. PubMed ID: 7341317.
    Abstract:
    Our study was undertaken in order to evaluate hemodynamic effects of intravenous administration of Reproterol in patients with chronic obstructive lung disease (COLD). Reproterol is a monomulecolar combination of catecholamine and theophilline. Diastolic pulmonary pressure and wedge pressure decreased 20 minutes after Reproterol while total pulmonary resistances were reduced 10 minutes after drug administration; sistolic pulmonary pressure and cardiac index increased only after 10 minutes; heart rate increased until 15th minute. Reproterol, as a catecholamine-theophylline combination, has an additional site of action over and above the pure catecholamine effect owing to inhibition of phosphodiesterase; so an increase in cAMP content is achieved either by increasing the synthesis or by blocking the breakdown. Our results assess that Reproterol has a beneficial effect on pulmonary hemodynamics in COLD.
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