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  • Title: Neuronal and liver protein synthesis in the developing offsprings following treatment of pregnant rats with ethanol or 1,3-butanediol.
    Author: Khawaja JA, Wallgren H, Usmi H, Hilska P.
    Journal: Res Commun Chem Pathol Pharmacol; 1978 Dec; 22(3):573-80. PubMed ID: 734235.
    Abstract:
    Ethanol or 1,3-butanediol ingestion during pregnancy and lactation results in a marked inhibition of neuronal protein synthesis in the 18-day-old rat progeny, however the same treatment had a stimulatory effect on the amino acid incorporation by neuronal perikarya of 8-day-old pups. Liver protein synthesis in vitro, on the other hand, was enhanced in both 8-day and 18-day-old pups as a consequence of maternal ethanol consumption. This was attributable to increased amino-acylation in the liver pH 5 enzyme fraction.
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