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  • Title: Mutagenicity and alpha-hydroxylation of N-nitrosopyrrolidine and N-nitrosopiperidine: a possible correlation.
    Author: Gilbert PJ, Rollmann B, Rondelet J, Mercier M, Poncelet F.
    Journal: Toxicology; ; 22(4):345-52. PubMed ID: 7342373.
    Abstract:
    N-Nitrosopyrrolidine (NPyrr) and N-nitrosopiperidine (NPip) are carcinogenic and mutagenic cyclic nitrosamines. Their biotransformation by rat liver post-mitochondrial fraction into 1,4-butanediol and 1,5-pentanediol, respectively, is evaluated by determining these ultimate metabolites with a sensitive and suitable method. Their mutagenic activity towards the Salmonella typhimurium strain TA 1530 was simultaneously observed. A relationship exists between their metabolism and their mutagenicity. alpha-Hydroxylation is probably the critical metabolic metabolism of cyclic nitrosamines.
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