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  • Title: Demonstration of high-affinity binding sites for C3a anaphylatoxin on guinea-pig platelets.
    Author: Becker S, Hadding U, Schorlemmer HU, Bitter-Suermann D.
    Journal: Scand J Immunol; 1978; 8(6):551-5. PubMed ID: 734357.
    Abstract:
    3H-serotonin release from guinea-pig platelets was demonstrated to be the consequence of C3a binding to these cells. A Scatchard analysis of dose-response data of the 125I-C3a binding pattern to guinea-pig platelets pointed to the existence of binding sites with high and low affinity for the C3a molecule (HA and LA receptors). HA receptors are specific for C3a with intact C-terminal arginine. whereas C3adesarg only interacts with LA receptors. The release of serotonin may be induced by a combined reaction of C3a with HA receptors and LA receptors on the platelet membrane.
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