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  • Title: Measurement of fibrinolytic activity after epsilon-aminocaproic acid administration in rats (Rattus norvegicus).
    Author: Gogjian MA, Barry KJ, Stein BM.
    Journal: Lab Anim Sci; 1981 Dec; 31(6):710-1. PubMed ID: 7343767.
    Abstract:
    The antifibrinolytic agent, epsilon-aminocaproic acid was administered to rats via either intraperitoneal injection or intravenous infusion. Time-response and dose-response studies of the resultant plasma levels of fibrinolytic activity were measured by a modification of a standard fibrin plate technique. The modified technique involved the addition of human plasma to rat plasma in a ratio of 10:1 (rat:human). The plasma levels of fibrinolytic activity reflected plasma concentrations of epsilon-aminocaproic acid.
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