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  • Title: Calcification in the human lens.
    Author: Fagerholm P, Philipson B, Carlström D.
    Journal: Curr Eye Res; ; 1(11):629-33. PubMed ID: 7346235.
    Abstract:
    A calcified cataractous lens from a 12 year old boy suffering from chronic uveitis was analysed using a microradiographic technique, X-ray crystallography and transmission electron microscopy. A 0.2 mm thick shell of calcified tissue was found in the subcapsular cortex. The mineral consisted of well-crystallized hydroxyapatite with a random orientation of the crystals. The underlying cortex consisted of a fibrous matrix containing collagen fibers. In the matrix, single or groups of epitheloid cells and fibroblast-like cells were found. Membrane-enclosed vesicles were found scattered in the matrix. The content of these vesicles had a wide range of electron density. A cell-induced mechanism for calcification is suggested.
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