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  • Title: Synthesis of 2-(trimethylsilyl)ethyloxycarbonylamino acids and their use in peptide chemistry.
    Author: Wünsch B, Moroder L, Keller O.
    Journal: Hoppe Seylers Z Physiol Chem; 1981 Sep; 362(9):1289-92. PubMed ID: 7346386.
    Abstract:
    2-(Trimethylsilyl)ethyl-4-nitrophenyl carbonate has been prepared as a new reagent for the introduction of the 2-(trimethylsilyl)ethyloxycarbonyl group into amino acids or amino acid derivatives. The resulting N alpha-protected amino acids were found to represent suitable intermediates for the synthesis of peptides. The amino-protecting group proved to be stable under the usual conditions of peptide synthesis and readily cleaved in selective conditions via fluoride ion-mediated fragmentation.
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