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  • Title: Effect of folate deficiency on microsomal drug metabolism and heme content in the intestinal mucosa of guinea pigs.
    Author: Clement RP, Tofilon PJ, Piper WN.
    Journal: Nutr Cancer; 1981; 3(2):63-71. PubMed ID: 7346792.
    Abstract:
    The relationship between folate deficiency, heme content, and microsomal drug metabolism in the intestinal mucosa of the guinea pig was examined. Weanling male guinea pigs were pair-fed a folate-deficient diet, and intestinal mucosal folate levels were measured. A significant decrease (75%) in these levels was observed at 3 weeks after diet initiation. A significant decrease (78%) in intestinal mucosal drug metabolism (7-ethoxycoumarin O-deethylase activity) and a significant decrease (46%) in intestinal mucosal heme content were also observed at this time. These findings indicate that folic acid deficiency in the guinea pig results in a marked reduction in heme content and microsomal drug metabolism of the intestinal mucosa.
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