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  • Title: CEA positivity in tissue and sera of patients with benign breast lesions.
    Author: Wittekind C, Von Kleist S, Sandritter W.
    Journal: Oncodev Biol Med; 1981; 2(6):381-90. PubMed ID: 7346797.
    Abstract:
    The presence of CEA was studied in paraffin sections of 100 benign breast lesions using an immunoperoxidase technique. In fibroadenomas, CEA was found in 25% of cases as opposed to 64% with cystic disease with or without epitheliosis. Our results demonstrate a tendency for an increased frequency of CEA tissue positivity in association with a more prominent form of epithelial hyperplasia with cystic disease. The observed higher positivity of tissue CEA may reflect a higher 'cellular activity' in the latter lesions compared with fibroadenomas.
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