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  • Title: [Influence of 4-methylesculetol on the response of segments of isolated coronary arteries to adrenaline, in presence of pyrogallol].
    Author: Bettini V, Baraldi S, Calcagno A, Legrenzi E, Mayellaro F, Martino R.
    Journal: Acta Vitaminol Enzymol; 1981; 3(4):236-43. PubMed ID: 7347133.
    Abstract:
    The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition. In order to test this hypothesis, we studied the influence of 4-methylesculetin (4-Me), alone or associated with ascorbic acid, on the response of isolated coronary strips to AD, in the presence of pyrogallol. Both 4-Me being enhanced by the addition of ascorbic acid. The effects were reduced or abolished in the presence off pyrogallol, a well known COMT inhibitor. It is concluded that 4-Me inhibits COMT, as other bioflavonoids.
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