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  • Title: Search for possible CNS depressant compounds: Part II. Synthesis of some new 1-(2'-methoxy-4'-nitrophenyl)-2-phenyl-4-substituted arylidene-5-imidazolones as CNS depressants.
    Author: Mukerji DD, Nautiyal SR, Prasad CR.
    Journal: Pol J Pharmacol Pharm; 1981; 33(6):633-7. PubMed ID: 7347813.
    Abstract:
    Some new 1-(2'-methoxy-4'-nitrophenyl)-2-phenyl-4-substituted benzylidene, furylidene and naphthylidene-5-imidazolones have been synthesized and tested on their CNS. anticonvulsant and analgesic activities in albino mice. At a dose of 200 mg/kg they displayed CNS depressant properties producing ataxia, decrease in spontaneous motor activity and loss of righting reflex. They also exhibited mild anticonvulsant activity in the pentetrazol test.
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