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Pubmed for Handhelds

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  • Title: Medical adrenalectomy in patients with advanced breast cancer resistant to anti-oestrogen treatment.
    Author: Murray RM, Pitt P.
    Journal: Breast Cancer Res Treat; 1981; 1(2):91-5. PubMed ID: 7348572.
    Abstract:
    Fifty-three women with actively progressing advanced breast cancer, who had all previously received tamoxifen, were treated with aminoglutethimide to induce medical adrenalectomy. Sixty-nine percent of the patients who had previously responded to tamoxifen subsequently responded to aminoglutethimide, while thirty-five percent of the nonresponders to tamoxifen subsequently responded to aminoglutethimide. The median duration of remission to aminoglutethimide was 12 months with a range from 4 to 22 + months. The drug was well tolerated and would appear to be the treatment of choice in tamoxifen responsive cases of advanced breast cancer.
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