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  • Title: Anesthetics and electroconvulsive therapy seizure duration: implications for therapy from a rat model.
    Author: Lunn RJ, Savageau MM, Beatty WW, Gerst JW, Staton RD, Brumback RA.
    Journal: Biol Psychiatry; 1981 Dec; 16(12):1163-75. PubMed ID: 7349626.
    Abstract:
    The anesthetic agents methohexital (Brevital), Innovar, and ketamine (Ketaject) were examined for their effect on seizure duration following electroconvulsive stimulation in a rat model of electroconvulsive therapy (ECT). Compared to unanesthetized control animals, methohexital anesthesia shortened seizure duration by 42%, ketamine anesthesia tended to increase seizure duration, and Innovar anesthesia had no effect on duration of seizures.
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