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  • Title: Effects of various gastrointestinal peptides on gastric somatostatin release.
    Author: Chiba T, Taminato T, Kadowaki S, Inoue Y, Mori K, Seino Y, Abe H, Chihara K, Matsukura S, Fujita T, Goto Y.
    Journal: Endocrinology; 1980 Jan; 106(1):145-9. PubMed ID: 7349951.
    Abstract:
    Effects of various gastrointestinal peptides on gastric somatostatin release from the isolated perfused rat stomach were studied. After isolation of the stomach in a fasted rat by the method of Lefébvre and preperfusion with 4.6% dextran-Krebs-Ringer bicarbonate buffer containing 5.5 mM glucose, each peptide was infused into the left gastric artery at a constant rate for 15 min. Secretin and bombesin caused a significant increase of gastric somatostatin release in a dose-related manner (10(-8)-10(-6) M). Gastric somatostatin release was also stimulated after the administration of pentagastrin (10(-8)-10(-6) M). In contrast, both methionine-enkephalin and substance P decreased gastric somatostatin release in a dose-related manner (10(-8)-10(-6) M), whereas neurotensin (10(-8)-10(-6) M) failed to change it significantly. The present results suggest that these various gastrointestinal peptides may regulate gastric somatostatin secretion.
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