These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The response of feline spinal pial arterioles to norepinephrine.
    Author: Crawford RA, Gregory PC, Griffiths IR.
    Journal: J Neurosurg; 1980 Jan; 52(1):60-3. PubMed ID: 7350281.
    Abstract:
    The effect of norepinephrine on the diameter of feline spinal pial arteries and arterioles was studied by microapplication of the drug to the perivascular environment. Vascular diameter was determined by the television image-splitting method. Application of norepinephrine over the range of 5 x 10(-8) M to 5 x 10(-3) M to spinal pial arterioles resulted in constriction of the vessels. The dose-response curve showed a tendency to plateau at concentrations above 5 x 10(-5) M, with a maximal constriction of 28.8 +/- 5.1% at 5 x 10(-3) M. The reduction in vessel diameter to microapplication of norepinephrine was prevented with the inclusion of an equimolar concentration of the alpha-adrenergic blocker, phentolamine, in the injectate. The data indicate the presence of alpha-adrenergic receptors on the smooth muscle of spinal pial arterioles, and it is suggested that the arguments pertaining to the sympathetic control of blood flow in the brain apply also to the spinal cord.
    [Abstract] [Full Text] [Related] [New Search]