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  • Title: Cefazolin in children with renal insufficiency.
    Author: Hiner LB, Baluarte HJ, Polinsky MS, Gruskin AB.
    Journal: J Pediatr; 1980 Feb; 96(2):335-9. PubMed ID: 7351609.
    Abstract:
    Cefazolin (7 mg/kg) were administered to 11 children with renal insufficiency and to ten children on hemodialysis. The serum half-life of the drug was progressively prolonged as glomerular filtration rate fell. The serum half-life of cefazolin was variably prolonged in those children on hemodialysis, but their serum levels of cefaxolin had dropped by 35 to 65% during dialysis. Most had no measurable level prior to the next dialysis. Dosage recommendations are made for both groups of patients.
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