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  • Title: Alkylation of nucleic acids by N-nitrosodi-n-propyl-amine: evidence that carbonium ions are not significantly involved.
    Author: Park KK, Archer MC, Wishnok JS.
    Journal: Chem Biol Interact; 1980 Feb; 29(2):139-44. PubMed ID: 7353229.
    Abstract:
    Administration of N-nitrosodi-n-propylamine to rats leads to the formation of 7-n-propylguanine but not 7-isopropylguanine in hepatic DNA. For RNA, a small amount of the rearranged adduct is formed. Alkylation of DNA and RNA therefore appears to occur primarily via a bimolecular reaction rather than a unimolecular pathway involving free alkyl cations.
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