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  • Title: Release of noradrenaline from the ligated cat hypogastric nerve.
    Author: Esquerro E, Ceña V, Sánchez-García P, Kirpekar SM, García AG.
    Journal: Eur J Pharmacol; 1980 Jan 25; 61(2):183-6. PubMed ID: 7353588.
    Abstract:
    After in vivo ligation for 24 of the cat hypogastric nerve, large amounts of noradrenaline (NA) and dopamine beta-hydroxylase (DBH) accumulated in the nerve segment immediately proximal to the ligature (P 1). In vitro incubation of 24-h-ligated nerves ((segments P1 and P2) in oxygenated Krebs solution at 37 degrees C in the presence of the ionophore X537A or high K+ concentrations caused a marked release of endogenously accumulated NA into the incubation medium. High-K+-evoked release was entirely dependent on extracellular Ca2+. Electrical nerve stimulation caused an 80% tissue NA loss, but the transmitter could not be found in the medium as intact NA. These results suggest that the in vivo ligated cat hypogastric nerve may serve as a useful model of adrenergic nerve terminals free of effector cells.
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