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  • Title: Distribution and tissue dose of intraperitoneally administered radioactive chromic phosphate (32P) in New Zealand white rabbits.
    Author: Leichner PK, Rosenshein NB, Leibel SA, Order SE.
    Journal: Radiology; 1980 Mar; 134(3):729-34. PubMed ID: 7355227.
    Abstract:
    Radiophosphorus (32P) has become the preferred radioisotope for intraperitoneal radiotherapy in the adjuvant treatment of ovarian cancer. In a study of the distribution and tissue dose of intraperitoneally administered 32P in rabbits, effective half-lives of 32P and the radiation dose absorbed by intra-abdominal tissues were determined. Results show that 32P is not uniformly distributed over the peritoneal surfaces and that many areas are minimally irradiated. It is concluded that a significant fraction of the 32P distribution is systemic and that the beta-ray dose for intra-abdominal tissues is much lower than suggested by theoretical models.
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