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  • Title: [Influence of duration and depth of ether of brevinarcon narcosis on the cerebral acetylcholine content of rat].
    Author: Weigel K, Schreyer K, Fischer HD.
    Journal: Acta Biol Med Ger; 1978; 37(4):681-4. PubMed ID: 735637.
    Abstract:
    For decapitation of rats in order to determine brain acetylcholine (Ach) content the animals may be anaesthesized slightly by ether no longer than for 2 min, since forebrain Ach content increases quickly up to about 170% throughout the following 3 min. The progress of brain Ach content up to its maximum level is decided both by duration and degree of cns depression: In the moment of most distinctly marked Brevinarcon -narcosis -- evident 2,5 min after i. v. injection (40 mg/kg) -- the forebrain Ach content merely is increased by about 15%, but when anaesthesia is reduced considerably again -- 2,5 min later -- the Ach content only reaches its maximum level.
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