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  • Title: Incidence of chromosomal rearrangements in couples with reproductive loss.
    Author: Kardon NB, Davis JG, Berger AL, Broekman A.
    Journal: Hum Genet; 1980 Feb; 53(2):161-4. PubMed ID: 7358381.
    Abstract:
    We report on 50 couples with reproductive loss did not have any detectable chromosome abnormality. A history of a previous child with multiple congenital abnormalities may be significant in identifying couples with a structural rearrangement. Only by studying more families can this hypothesis be tested. Studies of abortus tissue reveal a high percentage of chromosome abnormalities but a very low incidence of unbalanced translocations. Cytogenetic studies are indicated in a couple which has a past history of spontaneous abortions and a previous child with multiple congenital anomalies.
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