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  • Title: A comparison of pregnancy experience in DES-exposed and DES-unexposed daughters.
    Author: Herbst AL, Hubby MM, Blough RR, Azizi F.
    Journal: J Reprod Med; 1980 Feb; 24(2):62-9. PubMed ID: 7359503.
    Abstract:
    Reproductive histories were compared for 226 DES-exposed and 203 -unexposed daughters whose mothers participated in a double-blind evaluation 27 years before. Irregular menstruation was slightly more common among the exposed (10%) than among the unexposed (4%). Nineteen of the exposed and only four of the unexposed had primary infertility. Among those at risk, 86% of the unexposed and 67% of the exposed had become pregnant. The reasons for these differences are not known. Comparison of evaluable first pregnancy outcome revealed full-term live birth to be more common among the unexposed (85%) than the exposed (47%). Premature live birth was experienced by 22% of the exposed but only 7% of the unexposed. Nonviable outcomes of stillbirth, neonatal death, miscarriage and ectopic pregnancy occurred in 31% of the exposed and 8% of the unexposed. The difference in pregnancy outcomes between the groups is highly significant. The DES-exposed with transverse cervicovaginal ridges were more likely to experience a nonviable outcome. Overall 82% of the exposed and 93% of the unexposed had at least one live offspring. Reproductive histories were compared for 226 diethylstilbestrol (DES) exposed and 203 unexposed daughters whose mothers participated in a double-blind evaluation 27 years earlier. Complete prenatal medication records were available for 389 DES exposed and 395 unexposed daughters from the original study. Interviews were conducted from January 1978 to August 1979 at the time of follow-up gynecologic visits or by telephone or mail for those unable to come for an examination. Irregular menstruation was slightly more common among the exposed (10%) than among the unexposed (4%). 19 of the exposed and 4 of the unexposed had primary infertility. Among those at risk, 86% of the unexposed and 67% of the exposed had become pregnant; the reasons for these differences are unknown. Comparison of evaluable 1st pregnancy outcome revealed full-term live birth to be more common among the unexposed (85%) than the exposed (47%). Premature live birth was experienced by 22% of the exposed and 7% of the unexposed. Non-viable outcomes of stillbirth, neonatal death, miscarriage and ectopic pregnancy occurred in 31% of the exposed and 8% of the unexposed. The difference in pregnancy outcomes between the exposed and the unexposed groups is highly significant. The DES-exposed with transverse cervicovaginal ridges were more likely to experience a non-viable outcome. 82% of the exposed and 93% of the unexposed had at least 1 live offspring.
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