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  • Title: [Corticosteroids and the adrenaline activation of glycogen phosphorylase in heart tissue].
    Author: Seleznev IuM, Martynov AV.
    Journal: Probl Endokrinol (Mosk); 1980; 26(1):64-8. PubMed ID: 7360739.
    Abstract:
    Study of changes in the glycogen phosphorylase activity under the effect of adrenaline in the hearts of intact, adrenalectomized and sham-adrenalectomized rats demonstrated that stress increased the phosphorylase A level considerably. Against the background of these changes perfusion of the heart with 0.5.10(-7)M adrenaline produced no further elevation of the enzyme activity. Following restoration of the basal phosphorylase A to the normal level adrenaline again acquired the capacity to Phosphorylase activation. Stable absence of response of the heart tissue to adrenaline by increase of phosphorylase A activity was noted on the 5th postadrenalectomy day; this apparently followed disturbances in the potassium ions accumulation in the cells.
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