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  • Title: [Antitumor activity of the serum and lymphocytes of C57BL mice in chemical carcinogenesis].
    Author: Umanskiĭ IuA, Kushko LIa, Semenova-Kobzar' RA.
    Journal: Vopr Onkol; 1980; 26(2):42-6. PubMed ID: 7361493.
    Abstract:
    In chemical carcinogenesis induced by methylcholanthrene in mice C57BL the antitumor activity of sera ind lymphocytes are studied, which was assessed by their capacity to inhibit-stimulate spheroid formation by autologous tumor cells. The serum of animals being at the initial stage of the blastomatous process is found to inhibit the formation of spheroids but to reduce the functional activity of lymphocytes, while in the terminal stage of blastoma growth it contributes to the enhancement of tumor growth under direct interaction with cell-targets or indirectly through lymphocytes.
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