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  • Title: Vascular reactivity to angiotensin II in the normotensive and hypertensive pregnant ewe.
    Author: Lieb SM, Cabalum T, Zugaib M, Erkkola R, Tabsh K, Ushioda E, Nuwayhid BS, Brinkman CR, Assali NS.
    Journal: Am J Physiol; 1980 Feb; 238(2):H209-13. PubMed ID: 7361915.
    Abstract:
    The circulatory responses to progressively increasing doses of angiotensin II were studied in the same group of chronically instrumented unanesthetized pregnant sheep during three consecutive periods: a) normotensive with intact kidneys; b) normotensive with unilateral nephrectomy; and c) one-kidney hypertension. The results show that 1) the pressor response to a given dose of angiotensin was significantly greater in the normotensive than in the hypertensive condition; 2) uterine blood flow decreased markedly with the development of hypertension; 3) uterine circulatory response to angiotensin depended on the dosage; the response was less the the hypertensive than in the normotensive condition; 4) renal blood flow decreased and renal vascular resistance increased during angiotensin infusion, but the response was less in the hypertensive than in the normotensive condition; the response of the renal circulation decreased with increasing doses of angiotensin. These observations suggest a generalized vascular refractoriness to exogenous angiotensin II in the pregnant ewe with experimental renal hypertension.
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