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  • Title: Interaction between Pasteurella haemolytica and bovine alveolar macrophages: cytotoxic effect on macrophages and impaired phagocytosis.
    Author: Markham RJ, Wilkie BN.
    Journal: Am J Vet Res; 1980 Jan; 41(1):18-22. PubMed ID: 7362121.
    Abstract:
    Cultured bovine alveolar macrophages phagocytosed formalized 125I-labeled Pasteurella haemolytica organisms poorly when compared with uptake of an identical number of radiolabeled Yersinia enterocolitica organisms. The presence of immune serum enhanced uptake of P haemolytica, yet at high bacteria-to-macrophage ratios, a significant positive correlation existed between uptake and loss of cells from coverslips. This phenomenon was not observed with Y enterocolitica. While culture supernatant from P haemolytica either impaired phagocytosis or were cytotoxic to cultured macrophages, supernatant from Y enterocolitica did not show this effect. The observation of an apparent deterimental effect on bovine alveolar macrophages after uptake of P haemolytica may be used to explain events occurring in pneumonic pasteurellosis in cattle and may help in the development of immunizaiton techniques.
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