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  • Title: Single-dose kinetics predict steady-state concentrations on imipramine and desipramine.
    Author: Potter WZ, Zavadil AP, Kopin IJ, Goodwin FK.
    Journal: Arch Gen Psychiatry; 1980 Mar; 37(3):314-20. PubMed ID: 7362419.
    Abstract:
    Single-dose prediction of ultimate steady-state concentrations of tricyclic antidepressants at the outset of treatment can be a valuable therapeutic tool that has had only limited application. We demonstrate accurate steady-state predictions following both the tertiary amine, imipramine hydrochloride, and the secondary amine, desipramine hydrochloride, in a carefully monitored long-term treatment patient population. Results show that long-term treatment does not alter metabolism of either imipramine or desipramine. The relative merits of single-dose predictions using total and "abbreviated" areas under the curve and concentration at 24 hours are compared. These findings demonstrate that single-dose prediction can be used as a practical therapeutic, as well as, research tool.
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