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  • Title: Evidence for an intestinal Na+:sugar transport coupling stoichiometry of 2.0.
    Author: Kimmich GA, Randles J.
    Journal: Biochim Biophys Acta; 1980 Mar 13; 596(3):439-44. PubMed ID: 7362824.
    Abstract:
    Membrane potentials maintained by normally-energized intestinal epithelium interfere with an accurate determination of the Na+:sugar coupling stoichiometry associated with Na+-dependent transport systems. The interference is due to the fact that basal Na+ influx is itself a potential-dependent event, and sugar transport induces a membrane depolarization which therefore modifies basal Na+ entry. New information obtained under circumstances in which the membrane potential is maintained near 0 indicates that the true coupling stoichiometry is 2:1 rather than the commonly-accepted value of 1:1. A 2:1 stoichiometry means that cellular electrochemical Na+ gradients are adequate to account for recently observed 70-fold sugar gradients maintained by these cells under certain conditions.
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