These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of prostaglandins and indomethacin on neuromuscular blocking agents.
    Author: Hill GE, Wong KC.
    Journal: Can Anaesth Soc J; 1980 Mar; 27(2):146-9. PubMed ID: 7363143.
    Abstract:
    The effects on neuromuscular blockade by d-tubocurarine and succinylcholine of inhibition of prostaglandin biosynthesis by indomethacin and of intra-arterial administration of prostoglandins E2 and F2 alpha, before and after inhibition of prostoglandin biosynthesis, were evaluated in the cat sciatic-tibialis preparation. Non-specific inhibition of prostaglandin biosynthesis by indomethacin 3 mg . kg-1 did not alter latency, maximal blockade or duration of neuromuscular blockade induced by d-tubocurarine or succinylcholine. Prostaglandin E2 antagonized twitch height depression by d-tubocurarine by an average of six per cent before and by 15% after indomethacin, but potentiated the neuromuscular block of succinylcholine by an average of five per cent before and 60% after indomethacin. Prostaglandin F2 alpha antagonized d-tubocurarine neuromuscular block by an average of 10% before and 18% after indomethacin, but potentiated succinylcholine block by an average of four per cent before and 12% after indomethacin. These results suggest that non-specific inhibition of prostaglandin biosynthesis alone does not influence d-tubocurarine or succinylcholine induced neuromuscular blockades. However, both prostaglandin E2 and F2 alpha may induce transmitter release at the neuromuscular junction that may be enhanced by indomethacin, thus antagonizing the non-depolarizing blockade of d-tubocurarine and potentiating the depolarizing blockade of succinylcholine.
    [Abstract] [Full Text] [Related] [New Search]