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  • Title: Influence of cancer chemotherapy treatment on the reticuloendothelial system in the rat.
    Author: Ahlgren T, Berghem L, Grundfelt MB, Domellöf L.
    Journal: Chemotherapy; 1980; 26(2):128-34. PubMed ID: 7363707.
    Abstract:
    The phagocytic function of the reticuloendothelial system (RES) in the rat has been studied after the administration of cyclophosphamide, 5-fluorouracil or a combination of these drugs and vincristine. No impairment in the elimination of 125I-labelled microaggregated human serum albumin was found. A significant reduction in relative and total spleen weight was not paralleled by a decreased splenic uptake of the RES test substance per gram tissue. A significant increase in the relative weight of the lungs was paralleled by a significant increase in the uptake of test substance on a per gram basis. No correr. A general reduction in the cell population of the haematopoietic system has to be assumed. If this reduction is more pronounced in subpopulations of T lymphocytes (suppressor T cells) has to be further tested.
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