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  • Title: [Effect of theophylline-ethylenediamine in obstructive lung disease (author's transl)].
    Author: Brossmann D, Ruf G, Wiessmann KJ.
    Journal: Dtsch Med Wochenschr; 1980 Mar 21; 105(12):410-3. PubMed ID: 7363785.
    Abstract:
    In 12 patients with obstructive respiratory tract disease there occurred a decrease in the mean respiratory tract resistance of maximally 37% and a fall in pulmonary artery pressure of maximally 28% six hours after oral administration of 700 mg theophylline-ethylenediamine (Aminophyllin retard). The effect lasted beyond the 12 hours of observation on the first day and, after 14-day administration of twice daily 350 mg, remained nearly unchanged. After two weeks there was a clinically significant increase in vital capacity averaging 13%, the residual volume decreased by 14%.
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