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  • Title: Disseminated porokeratosis Mibelli treated with RO 10-9359. A study of two cases with ultrastructural remarks.
    Author: Bundino S, Zina AM.
    Journal: Dermatologica; 1980; 160(5):328-36. PubMed ID: 7364142.
    Abstract:
    2 patients with widespread porokeratosis Mibelli (PM) were treated orally with RO 10-9359. The dose was 75 mg/day for 10 days, then 50 mg/day for 3 weeks. The drug produced a good improvement of condition with no serious side effect. Ultrastructural examination of a healed lesion showed the presence of a fine granular substance in the intercellular space of the spinous layer, most likely produced by keratinocytes; ultrastructural cellular alterations of PM were still evident and the lesion recurred after suspension of treatment.
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