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  • Title: Evidence for both H and H2-histamine receptors in rabbit atria.
    Author: Srivastava RD.
    Journal: Indian J Physiol Pharmacol; 1980; 24(1):37-42. PubMed ID: 7364459.
    Abstract:
    Spontaneously beating isolated atria of rabbits responded to histamine (0.5-16 micrograms/ml) with positive chrono- and inotropism. However, the inotropic response was greater than chronotropic one. The concentration-response curve of histamine for chronotropic effect was markedly shifted to the right in the presence of 0.5 micrograms/ml metiamide (H2-receptor antagonist), which per se augmented the control contractile amplitude in all the experiments. The rightward shift of chronotropic concentration response curve with mepyramine (H1-antagonist) was, however, moderate. On the contrary, the inotropic concentration response curve of histamine was shifted to much greater extent to right with mepyramine (0.62 micrograms/ml) than with metiamide, thus suggesting a greater share of H1 than H2-receptors in the mediation of positive inotropic effect of histamine. The chronotropic effect appears to be mediated predominently by H2-receptors. Unlike metiamide, mepyramine did not alter the spontaneous frequency or amplitude of contraction. The present study, thus lends support for dual histamine receptors in rabbit atria.
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