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  • Title: Influence of hepatic and renal disorders on the pharmacokinetics of sulfachloropyridacine.
    Author: Mariño EL, Dominguez-Gil A, Tabernero JM, Macias JG.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1980 Jan; 18(1):10-4. PubMed ID: 7364528.
    Abstract:
    The pharmacokinetics of sulfachloropyridacine were studied in a series of 30 adult patients (healthy volunteers, patients with moderate hepatic impairment and patients with renal impairment). In all cases a 500 mg dose of sodium sulfachloropyridacine was administered orally. The drug follows a single compartment pharmacokinetic model. In healthy patients the following pharmacokinetic parameters were established: Ka = 5.130 h-1, Ke = 0.205 h-1, tmax = 40 min, Vd = 7.94 liters, and in patients diagnosed with cirrhosis a decrease is appreciable in the absorption constant and in the area below the blood-time levels curve. A linear relationship is established between the elimination constant and creatinine clearance. A dosage regimen, applicable to patients with renal impairment, is established as a function of the pharmacokinetic parameters. The degree of plasma protein binding of sulfachloropyridacine diminishes significantly in patients with renal impairment.
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