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  • Title: Viral hepatitis with extreme hyperbilirubinemia, massive hemolysis and encephalopathy in a patient with a new G6PD variant.
    Author: Sidi Y, Aderka D, Brok-Simoni F, Benjamin D, Ramot B, Pinkhas J.
    Journal: Isr J Med Sci; 1980 Feb; 16(2):130-3. PubMed ID: 7364565.
    Abstract:
    Extreme hyperbilirubinemia, massive hemolysis and hepatic encephalopathy were reported in a G6PD-deficient patient with viral hepatitis. Investigation of the G6PD properties revealed that this patient's enzyme represented a hitherto undescribed variant (Bnei Brak), characterized by heat stability and a unique triphasic pH-related enzyme activity curve. It is possible that the marked hemolytic process in this patient was enhanced by a further decrease in the activity of the already deficient enzyme during acidosis.
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