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  • Title: Lymphocyte activation in penicillin allergy: modification of the response to phytohaemagglutinin by benzylpenicilloylated human albumin.
    Author: Beucher F, Saurat JH.
    Journal: Ann Immunol (Paris); 1978; 129 C(5):611-5. PubMed ID: 736522.
    Abstract:
    Lymphocytes from twenty-six subjects, allergic or non-allergic to penicillin, were cultured together with phytohaemagglutinin (PHA) and penicillin. The antigen, benzylpenicilloylated human serum albumin (BPO-HSA), induced an enhanced proliferation with PHA in the allergic subjects, but a decreased proliferation with PHA in the non-allergic subjects treated by penicillin (p less than 0.01). The results are interpreted in terms of B- and T-cell regulations in the immune response of man to penicillin.
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