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  • Title: Progressive interstitial lung disease from prolonged methotrexate therapy.
    Author: Kaplan RL, Waite DH.
    Journal: Arch Dermatol; 1978 Dec; 114(12):1800-2. PubMed ID: 736591.
    Abstract:
    Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years. Examination revealed a combined restrictive and obstructive defect in pulmonary mechanics and severe compromise of gas transfer across the pulmonary alveolar-capillary membrane. Improvement in the level of arterial blood gases and pulmonary diffusing capacity occurred after discontinuation of methotrexate therapy. Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.
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