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  • Title: Rubella immunity: comparison of hemagglutination inhibition and radioimmunoassay antibody methods.
    Author: Harris RE, Smith KO, Gehle WD, Dupuy HJ.
    Journal: Obstet Gynecol; 1980 May; 55(5):603-7. PubMed ID: 7366918.
    Abstract:
    A threshold (1:10) rubella antibody hemagglutination inhibition (HAI) titer was obtained for 288 of 6537 (4.4%) obstetric patients. Random sera from 84 of these patients were compared for rubella antibody by both HAI and a very sensitive radioimmunoassay (RIA) technique. By RIA, 17% of the sera had no detectable rubella antibody, suggesting that those patients were truly susceptible to rubella. In addition, 8 of 55 paired prevaccine and postvaccine sera with titer increases demonstrated by HAI were analyzed by RIA. Seven of the 8 prevaccine sera were shown to have no rubella virus antibody by RIA, and RIA showed seroconversion in all 8 postvaccine sera.
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