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  • Title: Baroreflex control of heart rate in man awake and during enflurane and enflurane--nitrous oxide anesthesia.
    Author: Morton M, Duke PC, Ong B.
    Journal: Anesthesiology; 1980 Mar; 52(3):221-3. PubMed ID: 7369509.
    Abstract:
    Baroreflex control of heart rate was assessed by means of a pressor test in two groups of subjects while awake and at two levels of anesthesia with enflurane (Group I) and enflurane-nitrous oxide (Group II). In the awake control situation, calculated mean slopes (+/- SD) were 23 +/- 8 (Group I) and 25 +/- 11 (Group II). There was no significant difference between the groups. During enflurane anesthesia (Group I) mean slopes were significantly depressed to 5 +/- 5 at 1 MAC and 6 +/- 6 at 0.8 MAC. During enflurane-nitrous oxide anesthesia (Group II), slopes were significantly depressed to 5 +/- 3 at 1 MAC and 6 +/- 4 at 0.9 MAC. There was no significant difference between the extents of depression in the two groups. It is concluded that both enflurane anesthesia and enflurane-nitrous oxide anesthesia at 1 MAC produce significant depression of baroreflex control of heart rate in man.
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