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  • Title: Familial chondrocalcinosis. Prevalence in Northern Spain and clinical features in five pedigrees.
    Author: Rodriguez-Valverde V, Tinture T, Zuñiga M, Peña J, Gonzalez A.
    Journal: Arthritis Rheum; 1980 Apr; 23(4):471-8. PubMed ID: 7370061.
    Abstract:
    The first-degree consanguineous relatives of 46 patients with calcium pyrophosphate dihydrate (CPPD) crystal deposition disease were examined for the presence of articular chondrocalcinosis. In 5 cases the process was familial, with 17 persons in the oldest living generation (mean age 69 +/- 7.4) showing radiographic evidence of calcified cartilage. The clinical syndrome was characterized by a female predominance, late onset of symptoms with mild arthritic manifestations, and oligoarticular chondrocalcinosis. These data suggest that the familial type of CPPD crystal deposition disease is more frequent than formerly thought.
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