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  • Title: [Dopamine and renal homeostatic control of osmolarity and extracellular fluid volume in initial conditions of hydro-saline depletion and retention. I. Renal functional parameters].
    Author: Agnoli GC, Cacciari M, Garutti C, Lenzi P.
    Journal: Boll Soc Ital Biol Sper; 1980 Feb 15; 56(3):273-9. PubMed ID: 7370120.
    Abstract:
    Renal effects of dopamine (DA) infusion (0,1 micrograms.kg-1.min-1) in healthy human subject are strongly dependent on the basal condition of the extra-cellular fluid volume. The renal vasodilation and the inhibition of isosmotic sodium reabsorption (as % of sodium filtered load) induced by DA in hydro-saline retention are highly blunted in hydro-saline depletion. Moreover the inhibitory effect on anisosmotic sodium reabsorption (as % of sodium distal load), observed in hydro-saline retention, is reversed in hydro-saline depletion. Thus, DA is likely to behave as a sodium excretion regulator.
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