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  • Title: Unscheduled DNA synthesis in psoriatic skin after ultraviolet irradiation and the effects of a combined treatment with 8-methoxypsoralen and longwave ultraviolet radiation: a clinical study.
    Author: Bioulac P, Denechaud M, Dubuisson L, Doutre MS, Ducassou D, Beylot C.
    Journal: Br J Dermatol; 1980 Mar; 102(3):285-95. PubMed ID: 7370176.
    Abstract:
    Biopsies were taken from psoriatic patients undergoing photochemotherapy and then studied by autoradiography to investigate possible unscheduled DNA synthesis (UDS) following 8-MOP photodamage in epidermal cels. No sparse labelling was found in seventy samples taken from twenty-four different patients during PUVA therapy, indicating a lack of UDS. In contrast, UDS was observed in three patients irradiated with an all-spectrum UV lamp, as a test for DNA damage and excision repair activity. The incorporation of 3HTdR in these keratinocytes which were not undergoing S-phase was not affected by the dose of UV-A received during different stages of PUVA treatment. The results are discussed in terms of repair of the induced photodamage at the level of DNA, and in relation to a possible risk of this treatment when it is given over a long period of time.
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