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  • Title: [Hemopoietic action of the high-molecular fraction of leukocytic pyrogen].
    Author: Prigozhina TA, Kurbanova GN, Kakhetelidze MG, Sorokin AV, Rybakina EG.
    Journal: Biull Eksp Biol Med; 1980 Feb; 89(2):134-7. PubMed ID: 7370405.
    Abstract:
    During fractionation of the rabbit leukocytic pyrogen (LP) on Sephadex column and by the ethanol method, the apyrogenic protein fraction was isolated. In intact rats this fraction induced granulocytopoiesis stimulation: a rise in granulocyte proliferative activity, an increase in total granulocyte count in the bone marrow and peripheral blood, and also a rise in the number of macrocolonies in the spleen of lethally irradiated mice due to an increase in granulocyte colonies.
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