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  • Title: The radiobiological response of the thyroid. Part II: Response of sheep thyroid cell in vitro to single doses of X rays.
    Author: O'Connor MK, Malone JF, Moriarty M, Cullen MJ.
    Journal: Br J Radiol; 1980 Feb; 53(626):135-41. PubMed ID: 7370494.
    Abstract:
    The response of sheep thyroid cells in culture to single doses of X or gamma rays is described. In the absence of cellular proliferation the cells are unusually radioresistant, showing little sign of interphase death at doses up to 9 krad. The follicular morphology characteristic of thyroid cells in vivo is also very radioresistant. Iodide trapping is reduced to 50% of the control value by doses of the order of 2 krad. When proliferation is induced the cells may be assayed for postirradiation survival using a clonogenic endpoint. The survival curves are sigmoid with a Do of 410 rad and a very low extrapolation number.
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